Communicating with the description box with Trello Power-ups

I have a Trello Power-up that runs independently in an html popup when a card button is pressed. The power-up simply parses a .csv file and returns only my desired information in the html popup, which I then have to copy and paste into the description box. Is there any way to have this power-up output the information straight to the description box? How can I communicate with the description box in html5 and JavaScript?

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There isn’t a way to do this with the Power-Up platform alone. You will need to make use of the Trello REST API to update a card description. Take a look at the REST API Client for some sense of what is involved.